AUTISM AND GENETICS - CLINICAL APPROACH AND ASSOCIATION STUDY WITH 2 MARKERS OF HRAS GENE

作者:HERAULT J; PETIT E; MARTINEAU J; PERROT A; LENOIR P; CHERPI C; BARTHELEMY C; SAUVAGE D; MALLET J; MUH JP; LELORD G
来源:American Journal of Medical Genetics, 1995, 60(4): 276-281.
DOI:10.1002/ajmg.1320600404

摘要

Twin studies and familial aggregation studies indicate that genetic factors could play a role in infantile autism. In an earlier study, we identified a possible positive association between autism and a c-Harvey-ras (HRAS) oncogene marker at the 3' end of the coding region, In an attempt to confirm this finding, we studied a larger population, well-characterized clinically and genetically, We report a positive association between autism and two HRAS markers, the 3' marker used in the initial study and an additional marker in exon 1.

  • 出版日期1995-8-14

全文