Advances in the understanding of the Fanconi anemia tumor suppressor pathway

作者：Pickering Anna; Zhang Jun; Panneerselvam Jayabal; Fei Peiwen^*

来源：Cancer Biology and Therapy, 2013, 14(12): 1089-1091.

DOI：10.4161/cbt.26380

• the FA tumor suppressor pathway
• Rad6/Rad18 pathway
• DNA damage
• DNA polymerase eta
• translesion synthesis
• non-FA human tumors

Extremely high cancer incidence in Fanconi anemia (FA) patients has long suggested that the FA signaling pathway is a tumor suppressor pathway. Indeed, our recent findings, for the first time, indicate that the FA pathway plays a significant role in suppressing the development of non-FA human cancer. Also our studies on FA group D2 protein (FANCD2) have, among the first, documented the crosstalks between the FA and Rad6/Rad18 (HHR6) pathways upon DNA damage. In this review, we will discuss how our studies enhance the understanding of the FA tumor suppressor pathway.

• 出版日期2013-12