Association of metabolic syndrome and 25-hydroxyvitaminD with cognitive impairment among elderly Koreans

作者：Lee Eun Young; Lee Su Jin; Kim Kyoung Min; Yun Young Mi; Song Bo Mi; Kim Jong Eun; Kim Hyeon Chang; Rhee Yumie; Youm Yoosik; Kim Chang Oh^*

来源：Geriatrics and Gerontology International, 2017, 17(7): 1069-1075.

DOI：10.1111/ggi.12826

• cognitive impairment
• elderly
• metabolic syndrome
• vitaminD

AimMetabolic syndrome and vitaminD deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitaminD (25[OH]D) levels on cognitive function in older adults.
MethodsWe studied 2940 participants aged 65years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment PanelIII criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25-49, 50-74 and 75nmol/L. Cognitive function was assessed using the Mini-Mental State Examination.
ResultsParticipants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61-5.80) when compared with those with no metabolic syndrome and high 25(OH)D.
ConclusionsMetabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069-1075.

• 出版日期2017-7