A Phase Separation Model for Transcriptional Control

作者：Hnisz Denes; Shrinivas Krishna; Young Richard A^*; Chakraborty Arup K^*; Sharp Phillip A^*

来源：Cell, 2017, 169(1): 13-23.

DOI：10.1016/j.cell.2017.02.007

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.

• 出版日期2017-3-23
• 单位河北医科大学