SOX18 Expression Predicts Response to Platinum-based Chemotherapy in Ovarian Cancer

作者：Pula Bartosz^*; Kobierzycki Christopher; Solinski Daniel; Olbromski Matuesz; Nowak Markwitz Ewa; Spaczynski Marek; Kedzia Witold; Zabel Maciej; Dziegiel Piotr

来源：Anticancer Research, 2014, 34(8): 4029-4037.

• Ovarian cancer
• SOX18
• prognosis
• chemotherapy

Background: SOX18 is a transcription factor known to be involved in blood and lymphatic vessel, hair follicle development, and wound healing processes. In addition, it has been reported that SOX18 may influence cancer growth. The role of SOX18 expression in ovarian cancer (OC) has not been determined. Materials and Methods: SOX18 expression was assessed in 85 OC cases using immunohistochemical methods and in ovarian cancer cell lines on the mRNA and protein level. Results: SOX18 was expressed in cancer cell nuclei as well as the cytoplasm. Higher nuclear SOX18 expression was associated with presence of residual disease following surgical treatment (p=0.0158) and advanced disease stage (p=0.0056). Univariate survival analysis revealed that high SOX18 (p=0.0125) expression, presence of residual disease (p<0.0001) and advanced disease stage (p<0.0324) predicted poor patient outcome. Conclusion: SOX18 may be a new predictive marker for OC.

• 出版日期2014-8