Leucocyte Membrane-Coated Janus Microcapsules for Enhanced Photothermal Cancer Treatment

作者：He, Wenping; Frueh, Johannes^*; Wu, Zhenwei; He, Qiang^*

来源：Langmuir, 2016, 32(15): 3637-3644.

DOI：10.1021/acs.langmuir.5b04762

• ENCAPSULATED MATERIALS
• GOLD NANOPARTICLES
• THP-1 CELLS
• THERAPY
• PARTICLES
• NANOSHELLS
• ABLATION
• RADIOFREQUENCY
• PHTHALOCYANINE
• NANOSTRUCTURES

Polyelectrolyte multilayer (PEM) capsules are promising candidates for many kinds of cancer detection and treatment but are usually intended to deliver cargo to specific sites or to destroy cancer cells based on photothermal effects from the outside. In this publication we prove that it is possible to kill cancer cells from the inside based on phagocytosed PEM capsules. In addition we show how to open the cells and bring the PEM capsules to the surface of cancer cells based on photothermal effects and rapid evaporation of water. Diffusion-based temperature determinations of the photothermal effect up to the evaporation temperature of water are presented.

• 出版日期2016-4-19
• 单位哈尔滨工业大学