Pestarhamnoses A-C, Rhamnosylated Phenol Derivatives from the Soft Coral-Derived Fungus Pestalotiopsis sp.

作者：Xing, Qian^*; Li, Dan; Guo, Zhi-Yong; Wang, Chang-Yun; Shao, Chang-Lun

来源：Chemistry of Natural Compounds, 2015, 51(6): 1080-1084.

DOI：10.1007/s10600-015-1497-z

• rhamnosylated phenol derivative
• bromine-modified medium
• Pestalotiopsis sp.

Reinvestigation of the secondary metabolites of the soft coral-derived fungus Pestalotiopsis sp. (ZJ-2009-7-6), cultured in a bromine-modified medium, led to the isolation of three new rhamnosylated phenol derivatives, pestarhamnoses A-C ( 1 - 3 ), together with the former metabolites, (+/-)-pestalachlorides C and D ( 4 and 5 ). Their structures were elucidated through extensive 1D and 2D NMR spectroscopy and mass spectrometry. The relative configurations of the rhamnosyl moieties were determined as alpha-rhamnoses by their anomeric (1) J (CH) coupling constants. The absolute configurations of 1 - 3 were determined as L-rhamnose residues by HPLC analysis of their thiocarbamoyl-thiazolidine derivatives and that of authentic L-rhamnose. This is the first report of phenol glycosides with alpha-L-rhamnose in nature.

• 出版日期2015-11
• 单位中国海洋大学; 三峡大学