Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

作者:Bruns Danielle R; Drake Joshua C; Biela Laurie M; Peelor Frederick F III; Miller Benjamin F; Hamilton Karyn L
来源:Oxidative Medicine and Cellular Longevity, 2015, 2015: 732596.
DOI:10.1155/2015/732596

摘要

Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease. Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging. The transcription factor nuclear factor ( erythroid-derived 2)-like 2 is the "master regulator" of cellular antioxidant defenses. Nrf2 is upregulated by some longevity promoting interventions and may play a role in regulating species longevity. However, Nrf2 expression and activity in long-lived models have not been well described. Here, we review evidence for altered Nrf2 signaling in a variety of slowed aging models that accomplish lifespan extension via pharmacological, nutritional, evolutionary, genetic, and presumably epigenetic means.

  • 出版日期2015