New -glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam

作者：Onajobi Ismail B; Adhikari Achyut^*; Hussain Shabbir; Javaid Kulsoom; Fagade Obasola E; Oladosu I A

来源：Natural Product Research, 2016, 30(22): 2507-2513.

DOI：10.1080/14786419.2015.1115998

• Harungana madagascariensis
• madagascenone A and B
• -glucosidase inhibition

Two new 10-hydroxy-9(10H)-anthracenone, madagascenone A (1) and B (2), were isolated from the barks of Harungana madagascariensis Lam. The structures of the compounds were determined using 1D- and 2D-NMR and mass spectroscopic techniques. Both of the compounds showed an in vitro -glucosidase inhibition with IC50=69.9 +/- 4.21 and 122.3 +/- 1.13M, respectively, more potent than the standard acarbose (IC50=840 +/- 1.23M).

• 出版日期2016