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摘要
Liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) has recently become a more and more popular alternative to traditional ligand-binding assays for the quantitative determination of biopharmaceuticals. LC-MS-MS offers several advantages such as improved accuracy and precision, better selectivity, and generic applicability without the need for raising analyte-directed antibodies. Here we discuss the technical requirements for a successful LC-MS-MS method for the quantitation of biopharmaceuticals and evaluate the advantages and disadvantages compared to ligand-binding assays.
- 出版日期2015-10
