Norcantharidin analogues - Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines

作者：Deng, Liping; Shen, Li; Zhang, Jing; Yang, Bo; He, Qiaojun; Hu, Yongzhou^*

来源：Canadian Journal of Chemistry, 2007, 85(11): 938-944.

DOI：10.1139/V07-082

• norcantharidin analogues
• isoxazoline
• growth inhibition

A series of norcantharidin (NCTD) analogues have been synthesized by [3+2]1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with four nitrile oximes. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumor cell lines: KB, SGC-7901, HL60, Bel-7402, HO-8910, and ECA109, producing IC50 values from 0.36 mu mol/L to >100 mu mol/L. Compound 9d showed potency for the treatment of hepatoma, with IC50 value to Bel-7402 cell line comparable to that of norcantharidin.

• 出版日期2007-11
• 单位浙江大学