Long-term habituation of the startle response in mice evoked by acoustic and tactile stimuli

作者：Plappert CF^*; Pilz PKD

来源：Behavioural Brain Research, 2005, 162(2): 307-310.

DOI：10.1016/j.bbr.2005.03.022

• startle
• long-term habituation
• acoustic stimulus
• tactile stimulus
• mouse
• C57
• hearing loss
• auditory threshold

The present study shows that repetitive presentation of tactile and acoustic stimuli evoke Iona-term habituation (LTH) of the startle response in C57 BL/6J mice. This was indicated by a decrease in response strength over several days. For the LTH of the acoustic startle response two controls were included: first, developing hearing loss during the time of testing did not account for the startle decrease-only 7 days of acoustic stimulation but not 7 days of adaptation led to a decrease in the startle. Second, repetitive presentation Of loud acoustic startle stimuli did not raise the auditory threshold, which might otherwise have accounted for the startle decrease: prepulse inhibition (used here as a hearing test) was identical after both 7 days of acoustic startle stimulation and 7 days without stimulation. This proves that LTH to tactile and acoustic stimuli is present and fully functional in mice.

• 出版日期2005-7-30