A Novel Extracorporeal CO2 Removal System Results of a Pilot Study of Hypercapnic Respiratory Failure in Patients With COPD

作者：Burki Nausherwan K^*; Mani Raj Kumar; Herth Felix J F; Schmidt Werner; Teschler Helmut; Bonin Frank; Becker Heinrich; Randerath Winfried J; Stieglitz Sven; Hagmeyer Lars; Priegnitz Christina; Pfeifer Michael; Blaas Stefan H; Putensen Christian; Theuerkauf Nils; Quintel Michael; Moerer Onnen

来源：Chest, 2013, 143(3): 678-686.

DOI：10.1378/chest.12-0228

Background: Hypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated in these patients. %26lt;br%26gt;Methods: This is a pilot study of a novel ECCO2R device that utilizes a single venous catheter with high CO2 removal rates at low blood flows. Twenty hypercapnic patients with COPD received ECCO2R. Group 1 (n=7) consisted of patients receiving noninvasive ventilation with a high likelihood of requiring invasive ventilation, group 2 (n=2) consisted of patients who could not be weaned from noninvasive ventilation, and group 3 (n=11) consisted of patients on invasive ventilation who had failed attempts to wean. %26lt;br%26gt;Results: The device was well tolerated, with complications and rates similar to those seen with central venous catheterization. Blood flow through the system was 430.5 +/- 73.7 mL/min, and ECCO2R was 82.5 +/- 15.6 mL/min and did not change significantly with time. Invasive ventilation was avoided in all patients in group 1 and both patients in group 2 were weaned; PaCO2 decreased significantly (P%26lt;.003) with application of the device from 78.9 +/- 16.8 mm Hg to 65.9 +/- 11.5 mm Hg. In group 3, three Patients were weaned, while the level of invasive ventilatory support was reduced in three patients. One patient in group 3 died due to a retroperitoneal bleed following catheterization. %26lt;br%26gt;Conclusions: This single-catheter, low-flow ECCO2R system provided clinically useful levels of CO2 removal in these patients with COPD. The system appears to be a potentially valuable additional modality for the treatment of hypercapnic respiratory failure. Trial registry: ClinicalTrials.gov; No.: NCT00987740 and 01021605; URL: www.clinicaltrials.gov CHEST 2013; 143(3):678-686

• 出版日期2013-3