Toll-like receptors and cancer

作者:Rakoff Nahoum Seth*; Medzhitov Ruslan
来源:Nature Reviews Cancer, 2009, 9(1): 57-63.
DOI:10.1038/nrc2541

摘要

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.

  • 出版日期2009-1