A near infra-red spectroscopy study of the effects of pre-frontal single and paired pulse transcranial magnetic stimulation

作者：Thomson Richard H; Daskalakis Zafiris J; Fitzgerald Paul B^*

来源：Clinical Neurophysiology, 2011, 122(2): 378-382.

DOI：10.1016/j.clinph.2010.08.003

• Transcranial magnetic stimulation
• Paired pulse
• Cortical inhibition
• Cortical blood flow
• Oxygenated hemoglobin
• Pre-frontal cortex
• Brain stimulation

Objective: Concentration changes in hemoglobin following single and paired pulse (2 and 15 ms inter-stimulus interval) transcranial magnetic stimulation (TMS) was investigated using near infra-red spectroscopy (NIRS).
Methods: TMS was delivered to left pre-frontal cortex at typical intensities used in neuroscience research and concentrations of deoxyhemoglobin (Hb), oxyhemoglobin (HbO) and total hemoglobin (HbT) were measured.
Results: Significant drops in concentration of HbO and HbT were observed and while there was no effect of the different pulse types on amplitude, there was a difference in the time taken to return to baseline.
Conclusions: The changes observed imply that in pre-frontal cortex, the different TMS pulse types result in differential effects on oxygen consumption.
Significance: This study aids our understanding of the physiological effects of single and paired pulse TMS.

• 出版日期2011-2