Association of a missense mutation in the positional candidate gene glutamate receptor-interacting protein 1 with backfat thickness traits in pigs

作者：Lee Jae Bong; Park Hee Bok; Yoo Chae Kyoung; Kim Hee Sung; Cho In Cheol; Lim Hyun Tae^*

来源：Asian-Australasian Journal of Animal Sciences, 2017, 30(8): 1081-1085.

DOI：10.5713/ajas.16.0414

• Glutamate Receptor-interacting Protein 1 (GRIP1)
• Backfat
• Quantitative Trait Loci (QTL)
• Landrace
• Korean Native Pigs

Objective: Previously, we reported quantitative trait loci (QTLs) affecting backfat thickness (BFT) traits on pig chromosome 5 (SW1482-SW963) in an F2 intercross population between Landrace and Korean native pigs. The aim of this study was to evaluate glutamate receptor-interacting protein 1 (GRIP1) as a positional candidate gene underlying the QTL affecting BFT traits.
Methods: Genotype and phenotype analyses were performed using the 1,105 F2 progeny. A mixed-effect linear model was used to access association between these single nucleotide polymorphism (SNP) markers and the BFT traits in the F2 intercross population.
Results: Highly significant associations of two informative SNPs (c. 2442 T> C, c. 3316 C> G [R1106G]) in GRIP1 with BFT traits were detected. In addition, the two SNPs were used to construct haplotypes that were also highly associated with the BFT traits.
Conclusion: The SNPs and haplotypes of the GRIP1 gene determined in this study can contribute to understand the genetic structure of BFT traits in pigs.

• 出版日期2017-8