Regioselective Multicomponent Synthesis of Fully Substituted Pyrazoles and Bispyrazoles Catalyzed by Zinc Triflate

作者:Safaei Shirin; Mohammadpoor Baltork Iraj*; Khosropour Ahmad Reza; Moghadam Majid; Tangestaninejad Shahram; Mirkhani Valiollah
来源:Synlett, 2011, (15): 2214-2222.
DOI:10.1055/s-0030-1261202

摘要

A variety of fully substituted pyrazoles were easily prepared through a three-component condensation of aldehydes, arylhydrazines, and ethyl acetoacetate in the presence of catalytic amounts of zinc triflate [Zn(OTf)(2)] under solvent- free conditions. Selective synthesis of symmetrical and unsymmetrical bispyrazoles from dialdehydes in high yields can be considered as a notable advantage of this method.

  • 出版日期2011-9