Altered cortical thickness following prenatal sodium valproate exposure

作者：Wood Amanda G^*; Chen Jian; Barton Sarah; Nadebaum Caroline; Anderson Vicki A; Catroppa Cathy; Reutens David C; O'Brien Terence J; Vajda Frank

来源：Annals of Clinical and Translational Neurology, 2014, 1(7): 497-501.

DOI：10.1002/acn3.74

Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

• 出版日期2014-7