Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats

作者：Li, Yue; Li, Yicong^*; Gu, Peifei; Fu, Baojun; Liu, Fang; Li, Enyou

来源：Neuroscience Letters, 2011, 494(1): 6-9.

DOI：10.1016/j.neulet.2011.02.028

• Neuropathic pain
• gamma-Aminobutyric acid transporter-1
• inhibitor NO-711
• Withdrawal threshold
• Withdrawal latency

To investigate the analgesic effect of intrathecally administered gamma-aminobutyric acid (GABA) transporter] inhibitor NO-711 on the sciatic nerve chronic constriction injury (CCI) rats. 5 days after intrathecal catheter placement, neuropathic pain model was established by CCI of sciatic nerve on rats. Withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia were measured in all animals. All rats operated upon for CCI displayed decreased withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia, which has significant difference compared with sham groups. After intrathecal NO-711 administration, withdrawal thresholds and latency were significantly increased on CCI rats compared with control group after 1 day. The results show that GABA transporter-1 inhibitor could effectively develop analgesic effect in sciatic nerve CCI rats' model.

• 出版日期2011-4-20
• 单位哈尔滨医科大学; 中国人民解放军第二一一医院