N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase

作者：Pelcman Benjamin^*; Sanin Andrei; Nilsson Peter; Schaal Wesley; Olofsson Kristofer; Krog Jensen Christian; Forsell Pontus; Hallberg Anders; Larhed Mats; Boesen Thomas; Kromann Hasse; Claesson Hans Erik

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(15): 3017-3023.

DOI：10.1016/j.bmcl.2015.05.007

• 15-Lipoxygenase
• Inhibitors
• Arachidonic acid
• Pyrazole

High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors.

• 出版日期2015-8-1