Decreased Anterior Cingulate Cortex gamma-Aminobutyric Acid in Youth With Tourette's Disorder

作者：Freed Rachel D; Coffey Barbara J; Mao Xiangling; Weiduschat Nora; Kang Guoxin; Shungu Dikoma C; Gabbay Vilma^*

来源：Pediatric Neurology, 2016, 65: 64-70.

DOI：10.1016/j.pediatrneurol.2016.08.017

• Tourette's disorder
• GABA
• MRS
• adolescents
• children

BACKGROUND: gamma-Aminobutyric acid has been implicated in the pathophysiology of Tourette's disorder. The present study primarily sought to examine in vivo gamma-aminobutyric acid levels in the anterior cingulate cortex in psycho tropic medication-free adolescents and young adults. Secondarily, we sought to determine associations between gamma-aminobutyric acid in the anterior cingulate cortex and measures of tic severity, tic-related impairment, and anxiety and depression symptoms. METHODS: gamma-Aminobutyric acid levels were measured using proton magnetic resonance spectroscopy. Analysis of covariance compared gamma-aminobutyric acid levels in 15 youth with Tourette's disorder (mean age = 15.0, S.D. = 2.7) and 36 healthy comparison subjects (mean age = 15.9, S.D. = 2.1). Within the Tourette disorder group, we examined correlations between gamma-aminobutyric acid levels and tic severity and tic-related impairment, as well as anxiety and depression severity. RESULTS: Anterior cingulate cortex y-amino butyric acid levels were lower in participants with Tourette's disorder compared with control subjects. Within the Tourette disorder group, gamma-aminobutyric acid levels did not correlate with any clinical measures. CONCLUSIONS: Our findings support a role for gamma-aminobutyric acid in Tourette's disorder. Larger prospective studies will further elucidate this role.

• 出版日期2016-12