Mirin: identifying microRNA regulatory modules in protein-protein interaction networks

作者：Yang Ken Chi; Hsu Chia Lang; Lin Chen Ching; Juan Hsueh Fen^*; Huang Hsuan Cheng

来源：Bioinformatics, 2014, 30(17): 2527-2528.

DOI：10.1093/bioinformatics/btu306

A Summary: Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer.

• 出版日期2014-9-1