Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

作者：Ehsanian Reza^*; Van Waes Carter; Feller Stephan M

来源：Cell Communication and Signaling, 2011, 9(1): 13.

DOI：10.1186/1478-811X-9-13

This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-kappa B, p53, and AKT pathways are summarized.

• 出版日期2011-5-15