Comparison of Fenestra LC, ExiTron nano 6000, and ExiTron nano 12000 for Micro-CT Imaging of Liver and Spleen in Mice

作者：Boll Hanne; Figueiredo Giovanna; Fiebig Teresa; Nittka Stefanie; Doyon Fabian; Kerl Hans Ulrich; Noelte Ingo; Foerster Alex; Kramer Martin; Brockmann Marc A^*

来源：Academic Radiology, 2013, 20(9): 1137-1143.

DOI：10.1016/j.acra.2013.06.002

• Contrast agent
• micro-CT
• mice
• liver metastasis
• spleen tumor

Rationale and Objectives: The purpose of this study was to compare different contrast agents for longitudinal liver and spleen imaging in a mouse model of liver metastasis. %26lt;br%26gt;Materials and Methods: Mice developing liver metastases underwent longitudinal micro-computed tomography imaging after injection of Fenestra LC, ExiTron nano 6000, or ExiTron nano 12000. Elimination times and contrast enhancement of liver and spleen were compared. %26lt;br%26gt;Results: For all contrast agents, liver contrast peaked at approximately 4 hours and spleen contrast at 48 hours postinjection. A single dose of 100 mu L of ExiTron nano 6000 or 12000 resulted in longstanding enhancement of liver and spleen tissue for longer than 3 weeks, whereas repeated injections of 400 mu L of Fenestra LC were required to retain contrast at acceptable levels and allowed imaging of the liver/spleen for up to 2 and 9 days, respectively. %26lt;br%26gt;Conclusion: Both ExiTron nano agents provide longer and stronger contrast enhancement of liver and spleen compared to Fenestra LC, and they do so at a 75% lower injection volume in mice.

• 出版日期2013-9