Generation of PGS/PCL Blend Nanofibrous Scaffolds Mimicking Corneal Stroma Structure

作者：Salehi Sahar^*; Fathi Mohammadhossein; Javanmard Shaghayegh Haghjooy; Bahners Thomas; Gutmann Jochen S; Erguen Sueleyman; Steuhl Klaus P; Fuchsluger Thomas A

来源：Macromolecular Materials and Engineering, 2014, 299(4): 455-469.

DOI：10.1002/mame.201300187

• biodegradable
• elastomers
• electrospinning
• oriented fibers
• tissue engineering

Morphological studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(E-caprolactone)(PCL) blends for application as corneal tissue scaffolds are presented. Parallel conductive bars are used as ground electrode to generate unidirectional nanofibers. Scaffolds have fibers diameter in the range of 550-300nm. The structural stability and wettability, especially the in vitro degradation rate, of the electrospun scaffolds can be controlled by regulating the blended ratio of the polymers. The results indicate that PGS/PCL nanofiber scaffolds can be considered as ideal candidates for corneal tissue engineering scaffolds. The particular motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of the cornea.

• 出版日期2014-4