A SURFACE-BASED ELECTROPHYSIOLOGY MODEL RELYING ON ASYMPTOTIC ANALYSIS AND MOTIVATED BY CARDIAC ATRIA MODELING

作者：Chapelle Dominique^*; Collin Annabelle; Gerbeau Jean Frederic

来源：Mathematical Models and Methods in Applied Sciences, 2013, 23(14): 2749-2776.

DOI：10.1142/S0218202513500450

• Computational electrophysiology
• Asymptotic analysis
• Thin domains
• Cardiac modeling

Computational electrophysiology is a very active field with tremendous potential in medical applications, albeit it leads to highly intensive simulations. We here propose a surface-based electrophysiology formulation, motivated by the modeling of thin structures such as cardiac atria, which greatly reduces the size of the computational models. Moreover, our model is specifically devised to retain the key features associated with the anisotropy in the diffusion effects induced by the fiber architecture, with rapid variations across the thickness that cannot be adequately represented by naive averaging strategies. Our proposed model relies on a detailed asymptotic analysis in which we identify a limit model and establish strong convergence results. We also provide detailed numerical assessments that confirm an excellent accuracy of the surface-based model-compared with the reference 3D model -including in the representation of a complex phenomenon, namely, spiral waves.

• 出版日期2013-12
• 单位INRIA