CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid

作者：Asano Kenichi^*; Kikuchi Kenta; Tanaka Masato

来源：Journal of Biochemistry, 2018, 164(2): 77-85.

DOI：10.1093/jb/mvy050

• CCL8
• CD169
• intestinal inflammation
• macrophage
• tolerance

Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169 + macrophages in the lymphoid organs capture blood-and lymph-borne particulate materials. Antigen information relayed by CD169 + macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169 + macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169 + macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.

• 出版日期2018-8