A Chemoselective, One-Pot Transformation of Aldehydes to Nitriles

作者:Laulhe Sebastien; Gori Sadakatali S; Nantz Michael H*
来源:Journal of Organic Chemistry, 2012, 77(20): 9334-9337.
DOI:10.1021/jo301133y

摘要

This paper describes a procedure for direct conversion of aldehydes to nitrites using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly transformed to their corresponding nitriles by heating with DPPH in toluene. The reaction can be accomplished in the presence of alcohol, ketone, ester, or amine functionality.

  • 出版日期2012-10-19