A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH3O-PEG-phosphatide

作者：Yang, Huan; Liang, Hongjuan; Xie, Yuwen; Chen, Qiuyun^*

来源：Chinese Chemical Letters, 2018, 29(10): 1528-1532.

DOI：10.1016/j.cclet.2018.02.011

• Activable sensor
• Protein-inorganic nanoparticle
• Cancer
• CH3O-PEG-phosphatide
• Attenuator

Cancer activated protein-inorganic nanoparticles can be cancer targeting turn-on imaging and therapy agents. Although various techniques were successfully employed for development of hybrid protein-inorganic nanoparticles, cancer cell activated protein-inorganic nanoparticles have been challengeable. Herein, a cancer cell responsive nanoparticle (PDAMn-CuS@BSA-FA, NPs) was constructed and characterized. It is found that the quenching interaction of dyes (PDA) and central metal in NPs can be adjusted by CH3O-PEG-phosphatide or the cancer cells, hence, NPs showed turn-on fluorescence emission with the titration of CH3O-PEG-phosphatide. In particular, breast cancer cells lysis can switch on the green emission greatly, while normal cells show less effect. Breast cancer cells turn-on fluorescence imaging and mitochondria targeting imaging demonstrate that the NPs can sense breast cancer cells and enter mitochondria. Therefore, NPs can be both breast cancer targeting nanosensor.

• 出版日期2018-10
• 单位江苏大学