Macrophage Activation Syndrome

作者：Ravelli Angelo^*; Davi Sergio; Minoia Francesca; Martini Alberto; Cron Randy Q

来源：Hematology-Oncology Clinics of North America, 2015, 29(5): 927-+.

DOI：10.1016/j.hoc.2015.06.010

• Macrophage activation syndrome
• Systemic juvenile idiopathic arthritis
• Hemophagocytic lymphohistiocytosis
• Hemophagocytic syndrome
• Proinflammatory cytokines
• Interleukin-1 inhibitors

Macrophage activation syndrome (MAS) is a potentially life-threatening complication of rheumatic disorders that occurs most commonly in systemic juvenile idiopathic arthritis. In recent years, there have been several advances in the understanding of the pathophysiology of MAS. Furthermore, new classification criteria have been developed. Although the place of cytokine blockers in the management of MAS is still unclear, interleukin-1 inhibitors represent a promising adjunctive therapy, particularly in refractory cases.

• 出版日期2015-10