Mitochondrial involvement in psychiatric disorders

作者：Shao Ling; Martin Maureen V; Watson Stanley J; Schatzberg Alan; Akil Huda; Myers Richard M; Jones Edward G; Bunney William E; Vawter Marquis P^*

来源：Annals of Medicine, 2008, 40(4): 281-295.

DOI：10.1080/07853890801923753

• bipolar disorder
• major depressive disorder
• mitochondria
• mtDNA
• schizophrenia

Recent findings of mitochondrial abnormalities in brains from subjects with neurological disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. A growing body of evidence suggests that there is mitochondrial dysfunction in schizophrenia, bipolar disorder, and major depressive disorder, including evidence from electron microscopy, imaging, gene expression, genotyping, and sequencing studies. Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examination of mitochondrial DNA from postmortem brain cells may provide further details of mitochondrial alterations in psychiatric disorders.

• 出版日期2008