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摘要
A novel and efficient synthesis of 11-fluoro-11H-indeno[1,2-c]quinolines has been developed via a palladium-catalyzed three-component reaction of 2-alkynylbromobenzenes, 2-alkynylanilines, and N-fluorobenzenesulfonimide. The reaction works well with high selectivity. Additionally, the diversity and complexity could be easily introduced via a simple operation from readily available starting materials. In the meantime, a fluorine atom could be incorporated into the scaffold during the reaction process.
