科研之友
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摘要
Background: Red wine consumption may influence on vasoconstrictive peptide endothelin-1 levels, and this may be one mechanism leading to improved vasodilation after red wine consumption. Endothelin-1 levels and their association with coronary epicardial diameter and. flow rate, however, have not been studied in vivo after consumption of red wine and de-alcoholized red wine. The purpose of this randomized trial was to determine the acute effects of these beverages on endothelin-1 levels and compare them to coronary artery epicardial diameter and. flow rate.
Methods: Twenty-two healthy men consumed a high dose (8.1 +/- 0.9 dL) of alcohol-containing red wine and de-alcoholized red wine in a cross-over design at one sitting with a two-week washout period. Endothelin-1 levels were determined and coronary artery diameter and. flow rate assessed using transthoracic echocardiography before and acutely after intervention.
Results: Red wine and de-alcoholized red wine significantly decreased endothelin-1 levels (0.75 +/- 0.26 pg/mL to 0.61 +/- 0.20 pg/mL, p = 0.002; 0.74 +/- 0.32 pg/mL to 0.63 +/- 0.24 pg/mL, p = 0.04, respectively), but did not have a significant effect on epicardial diameter (1.1 +/- 0.3 mm vs. 1.1 +/- 0.3 mm, p = 0.58; and 1.1 +/- 0.3 mm vs. 1.1 +/- 0.2 mm, p = 0.10, respectively) or. flow rate (7.8 +/- 4.0 mL/min to 6.4 +/- 3.6 mL/min, p = 0.07; and 7.8 +/- 4.0 mL/min to 7.4 +/- 3.2 mL/min, p = 0.53, respectively).
Conclusions: Red wine and de-alcoholized red wine decreased plasma endothelin-1 levels after acute consumption, but this change was not reflected in coronary epicardial diameters or. flow rate.
- 出版日期2010-7
