First synthesis of nitrosporeusines, alkaloids with multiple biological activities

作者：Philkhana Satish Chandra; Jachak Gorakhnath R; Gunjal Vidya B; Dhage Nagsen M; Bansode Ajay H; Reddy D Srinivasa^*

来源：Tetrahedron Letters, 2015, 56(10): 1252-1254.

DOI：10.1016/j.tetlet.2015.01.143

• Influenza H1N1 virus
• Michael reaction
• Enzymatic resolution
• Nitrosporeusine
• Maleimycin

Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product, maleimycin, in optically pure form using a gram-scale enzymatic resolution method.

• 出版日期2015-3-4