A Smart Hyperthermia Nanofiber with Switchable Drug Release for Inducing Cancer Apoptosis

作者：Kim Young Jin^*; Ebara Mitsuhiro; Aoyagi Takao

来源：Advanced Functional Materials, 2013, 23(46): 5753-5761.

DOI：10.1002/adfm.201300746

• magnetic nanoparticles
• electrospinning
• smart nanofiber
• hyperthermia
• temperature-responsive polymers

A smart hyperthermia nanofiber is described with simultaneous heat generation and drug release in response to on-off%26apos; switching of alternating magnetic field (AMF) for induction of skin cancer apoptosis. The nanofiber is composed of a chemically-crosslinkable temperature-responsive polymer with an anticancer drug (doxorubicin; DOX) and magnetic nanoparticles (MNPs), which serve as a trigger of drug release and a source of heat, respectively. By chemical crosslinking, the nanofiber mesh shows switchable changes in the swelling ratio in response to alternating on-off%26apos; switches of AMF because the self-generated heat from the incorporated MNPs induces the deswelling of polymer networks in the nanofiber. Correspondingly, the on-off%26apos; release of DOX from the nanofibers is observed in response to AMF. The 70% of human melanoma cells died in only 5 min application of AMF in the presence of the MNPs and DOX incorporated nanofibers by double effects of heat and drug. Taken together these advantages on both the nano- and macroscopic scale of nanofibers demonstrate that the dynamically and reversibly tunable structures have the potential to be utilized as a manipulative hyperthermia material as well as a switchable drug release platform by simple switching an AMF on%26apos; and off%26apos;.

• 出版日期2013-12-10