Association between the polymorphism of glutathione S-transferase genes (GSTM1, GSTT1, and GSTP1) and vitiligo: a meta-analysis

作者：Park Hyun Kyung; Kim Hee Sung^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(7): 6617-6625.

• Glutathione S-transferase gene
• polymorphism
• meta-analysis
• vitiligo

Several evidences indicate that the imbalance between oxidative stress and antioxidation in the epidermal layer of skin may be an important pathogenetic factor of vitiligo. Polymorphisms in the glutathione S-transferase (GST) genes have been identified, which confer risk of vitiligo. There is an impairment of antioxidative system in vitiligo melanocytes with result from free radical mediated damage in melanocyte. The associations between polymorphisms of GSTM1/T1/P1 genes and vitiligo susceptibility have produced diverse results. We conducted a meta-analysis of all relevant study in EMBASE, GOOGLE, KISS, MEDLINE and PubMed before January 2015. In present study, a meta-analysis on the association between the GSTM1/T1 polymorphism and vitiligo was performed for 1,258 patients with vitiligo and 1,573 controls from eligible 5 published studies. The results in our meta-analysis showed that the null type of GSTM1 and null type of GSTT1 genotype was significantly associated with vitiligo (GSTM1, OR=1.494, 95% CI=1.126-1.981, P=0.005; GSTT1, OR=1.318, 95% CI=1.130-1.537, P<0.001). In the subgroup analysis, the null type frequency of the combination of GSTM1-GSTT1 polymorphism in the vitiligo was significantly higher than that of the control group (OR=1.369, 95% CI=1.149-1.633, P<0.001). This result indicated that null type of GSTM1-GSTT1 combination can be a risk factor of vitiligo. However, further lager study considering the gene-gene and gene-environment interactions could be required to provide a very precise evidence for the association of GST polymorphism and the vitiligo susceptibility.

• 出版日期2016