A Hybrid Plasmonic Bimetallic Nanoshell-Microsphere Sensor for Cancer Market Protein Detection

作者：Garaei Marzieh Afkhami; Saliminasab Maryam; Nadgaran Hamid^*; Moradian Rostam

来源：Plasmonics, 2017, 12(6): 1953-1960.

DOI：10.1007/s11468-016-0467-z

• Bimetallic nanoshell
• Microsphere
• Raman scattering
• Surface plasmon resonance

In this paper, the detection of a thyroid cancer market (Thyroglobulin, Tg) protein has demonstrated by using a hybrid plasmonic bimetallic nanoshell-microsphere sensor based on the reactive sensing principal (RSP). Tunable optical properties and plasmon resonances at three frequencies made a bimetallic nanoshell more special for sensing purposes. The rough surface of the bimetallic nanoshell affixed to the microsphere surface locally enhanced the electric field within the microcavity without significantly degrading a Q-factor (similar to 7.59 x 10(5)), at near infrared wavelength. The rough surface of the bimetallic nanoshell effectively enhanced a wavelength shift of the hybrid microcavity by the factor of similar to 300. At lower energy mode, the electric field enhancement of the hybrid plasmonic microsphere resonator increases by similar to 863% at the surface of the bump in comparison with a smooth nanoshell. This enhancement occurs in rough bimetallic nanoshell as localized surface Plasmon resonance (LSPR), which increases the Raman signal through the surface Raman scattering (SERS) effect in hybrid microcavity. Calculated results demonstrate that the hybrid plasmonic microsphere resonator can generate very strong SERS enhancement factor at a visible wavelength (similar to 1.5 x 10(7)).

• 出版日期2017-12