Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages

作者：Park Ji Won; Kwon Ok Kyoung; Ryu Hyung Won; Paik Jin Hyub; Paryanto Imam; Yuniato Prasetyawan; Choi Sangho; Oh Sei Ryang; Ahn Kyung Seop^*

来源：International Journal of Molecular Medicine, 2018, 41(6): 3709-3716.

DOI：10.3892/ijmm.2018.3559

• Passiflora foetida L
• inflammation
• lipopolysaccharide
• MAPK
• nuclear factor-kappa B

Passiflora foetida L. (Passifloraceae), a perennial climber in general, is used for treating many ailments in conventional medicine. In this study, the anti-inflammatory effect of methanolic extracts of P. foetida L. (PFME) and the involvement of nuclear factor-B (NF-B) signalling in the regulation of inflammation were investigated. PFME prevented the production of prostaglandin E-2 (PGE(2)) and the expression of inducible cyclooxygenase-2 (COX-2) in lipopoly-saccharide (LPS)-induced macrophage cells. Additionally, PFME reduced the release of pro-inflammatory cytokines. Moreover, in LPS-induced RAW264.7 cells, the phosphorylation of MAPKs (ERK1/2, p38 and JNK) was suppressed by PFME. Furthermore, PFME inhibited the NF-B activation induced by LPS, which was associated with nuclear p65 levels with the abrogation of IB degradation and subsequent decreases. These results indicated that the PFME inhibited the LPS-induced inflammatory and oxidative responses. Therefore, we propose that the PFME may be therapeutic for treating inflammatory diseases.

• 出版日期2018-6