Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication

作者：Radua J; Borgwardt S; Crescini A; Mataix Cols D; Meyer Lindenberg A; McGuire P K; Fusar Poli P^*

来源：Neuroscience and Biobehavioral Reviews, 2012, 36(10): 2325-2333.

DOI：10.1016/j.neubiorev.2012.07.012

• Antipsychotic
• First episode psychosis
• Functional magnetic resonance imaging
• Meta-analysis
• Schizophrenia
• Neuroimaging
• Voxel-based morphometry
• Psychosis

Structure and function in the human brain are closely related. At the onset of psychosis, brain imaging studies have identified robust changes in brain function and structure, but no data are available relating these two domains. After systematic literature searches, we included all available studies reporting whole-brain structural or cognitive functional imaging findings in first-episode (FEP) subjects in multi-modal Signed Differential Mapping (5DM). Forty-three studies met the inclusion criteria. The structural database comprised 965 FEP subjects matched with 1040 controls whilst the functional cohort included 362 FEP subjects matched with 403 controls. The analysis identified conjoint structural and functional differences in the insula/superior temporal gyrus and the medial frontal/anterior cingulate cortex bilaterally. In these regions, large and robust decreases in grey matter volume were found with either reduced or enhanced activation. Meta-regression analyses indicated that grey matter volume in the anterior cingulate and left insular clusters was influenced by exposure to antipsychotics: patients receiving medication were more likely to show structural abnormalities in these regions.

• 出版日期2012-11
• 单位上海市精神卫生中心