A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

作者：Surakka Ida; Whitfield John B; Perola Markus; Visscher Peter M; Montgomery Grant W; Falchi Mario; Willemsen Gonneke; de Geus Eco J C; Magnusson Patrik K E; Christensen Kaare; Sorensen Thorkild I A; Pietilainen Kirsi H; Rantanen Taina; Silander Kaisa; Widen Elisabeth; Muilu Juha; Rahman Iffat; Liljedahl Ulrika; Syvanen Ann Christine; Palotie Aarno; Kaprio Jaakko; Kyvik Kirsten O; Pedersen Nancy L; Boomsma Dorret I; Spector Tim; Martin Nicholas G

来源：Twin Research and Human Genetics, 2012, 15(6): 691-699.

DOI：10.1017/thg.2012.63

• twins
• association
• lipids
• apolipoproteins
• interaction

Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98x10(-8)). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03x10(-8)).

• 出版日期2012-12
• 单位河北医科大学