Atropisomeric small molecule Bcl-2 ligands: Determination of bioactive conformation

作者：Porter John^*; Payne Andrew; Whitcombe Ian; de Candole Ben; Ford Daniel; Garlish Rachel; Hold Adam; Hutchinson Brian; Trevitt Graham; Turner James; Edwards Chloe; Watkins Clare; Davis Jeremy; Stubberfield Colin

来源：Bioorganic & Medicinal Chemistry Letters, 2009, 19(6): 1767-1772.

DOI：10.1016/j.bmcl.2009.01.071

• Bcl-2
• Protein-protein interaction
• Apoptosis
• Atropisomerism

The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.

• 出版日期2009-3-15