Kinetic changes of intestinal microbiota in the course of intestinal sensitization

作者：Xiao, Liang; Yang, Bo; Liu, Xiaoyu; Luo, Yan; Ji, Qiongmei; Wen, Zhong^*; Liu, Zhigang^*; Yang, Ping-Chang^*

来源：Oncotarget, 2016, 7(49): 81197-81207.

DOI：10.18632/oncotarget.12797

• food allergy
• intestine
• microbiota
• 16S rRNA
• animal model

Food allergy (FA) is an adverse immune response to certain innocent food. It is estimated about 2% to 6% of the general population suffer from FA. Symptoms of a food allergic reaction may involve the gastrointestinal tract or/and other organs. The gut microbiota plays a critical role in diet-induced health problems. Whether the changes in the composition of the intestinal microbiota regulate allergic responses to food remains poorly understood. Thus, we created an FA animal model, sequenced the V4-V5 regions of 16S rRNA genes to characterize the genera abundance of gut microbiota. The results showed that mice under FA condition showed different gut bacterial structures. Diverse distribution of the bacterial species was identified between FA and control groups. FA altered the components of intestinal Microbiota in mice. The dysbiosis of the gut metagenome correlated with the development of the FA.

• 出版日期2016-12-6
• 单位深圳华大生命科学研究院; 南方医科大学; 深圳大学