AZACITIDINE FOR ACUTE MYELOID LEUKEMIA AND MYELODYSPLASTIC SYNDROME

作者：Gritsaev S V^*; Martynkevich I S; Kostroma I I

来源：Gematologiya i Transfuziologiya, 2012, 57(1): 23-29.

• acute myeloid leukemia
• myelodysplastic syndrome
• 5-azacitidine

The results of two randomized studies, CALGB 9221 and AZA-001, demonstrated the clinical advantages of 5-azacitidine in patients with the intermediate-2 and high risk myelodysplastic syndrome (according to IPSS) in comparison with the standard therapy. The efficiency of 5-azacitidine in patients with low risk myelodysplastic syndrome is analyzed. Search for clinical laboratory parameters associated with the probability of response to 5-azacitidine therapy has been carried out.

• 出版日期2012-2