An Efficient Three-Component Synthesis of 3-(1-Hydroxyalkyl)[1,2,4]-triazolo[4,3-c]quinazolines

作者：Adib Mehdi^*; Ansari Samira; Feizi Shahzad; Bijanzadeh Hamid Reza

来源：Synlett, 2010, (6): 921-923.

DOI：10.1055/s-0029-1219562

• N-isocyaniminotriphenylphosphorane
• 4(3H)-quinazolinones
• aldehydes
• 3-(1-hydroxyalkyl)[1,2,4]triazolo[4,3-c]quinazolines
• multicomponent reactions
• cyclizations
• heterocycles

An efficient three-component synthesis of 3-(1-hydroxyalkyl)[1,2,4] triazolo[4,3-c] quinazolines is described. A mixture of N-isocyaniminotriphenylphosphorane, an aldehyde, and a 4(3H)quinazolinone undergo a 1:1:1 addition reaction in refluxing THF to afford the title compounds in good to excellent yields.

• 出版日期2010-4