Association between Neurotrophin-3 Polymorphisms and Executive Function in Japanese Patients with Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease

作者：Kobayashi Nobuyuki; Nagata Tomoyuki^*; Shinagawa Shunichiro; Nakayama Ritsuko; Kondo Kazuhiro; Nakayama Kazuhiko; Yamada Hisashi

来源：Dementia and Geriatric Cognitive Disorders, 2012, 34(3-4): 190-197.

DOI：10.1159/000343075

• Neurotrophin-3
• Alzheimer disease
• Executive function
• Frontal assessment battery

Background: We investigated whether neurotrophin (NT)-3 polymorphisms influenced the executive function of patients with 2 separate disease stages with similar dementia conditions: amnestic mild cognitive impairment (A-MCI) or mild Alzheimer disease (AD). Methods: Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630. Next, we compared the frontal assessment battery (FAB) total and subtest scores between the three genotypic groups. Results: The total FAB score was not significantly associated with the rs6332 and rs6489630 genotypes; however, the conflicting instructions score among the 6 subtests was significantly associated with the rs6332 genotype (p %26lt; 0.05). Moreover, in patients with mild AD, the conflicting instructions score differed significantly among the three genotypic groups of rs6332 (p %26lt; 0.05) (G/G %26lt; A/A: p = 0.042 and G/A %26lt; A/A: p = 0.041). No significant differences in any other demographic variables were observed among the three genotypes of rs6332 and rs6489630. Conclusion: These results suggested that an NT-3 polymorphism, rs6332, may significantly influence executive function, reflecting interference performances among patients with mild-stage AD.

• 出版日期2012