摘要

PTH1R is a strong candidate gene for OCD, identified in both horses and pigs, indicating the potential for involvement of pathways that mediate transition from cartilage to bone during endochondral ossification and growth plate maturation. Genes identified include secreted proteins of the extracellular matrix and the genes encoding proteins that mediate the cellular secretory pathway. The identified genetic loci may also indicate a higher risk for osteoarthritis.

  • 出版日期2014-4