Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

作者：Li, Chunyan; Liu, Zheshuo; Yan, Xueying; Lu, Weiyue; Liu, Yu^*

来源：International Journal of Pharmaceutics, 2015, 479(1): 261-264.

DOI：10.1016/j.ijpharm.2014.12.011

• Phenyboronic acid
• Nanoparticle
• Mucoadhesion
• Controlled release
• Mucin

Phenylboronic acid-rich nanoparticles (PBNPs) were designed as a novel mucoadhesive vaginal drug delivery system. PBNPs effectively adsorbed mucin in vitro and could be easily loaded with the model drug interferon (IFN). Drug release from PBNPs was controlled by the presence of mucin. Neither obvious cytotoxicity nor vaginal histological changes in mice caused by PBNPs or IFN-loaded PBNPs were observed.

• 出版日期2015-2-1
• 单位复旦大学; 黑龙江中医药大学