Novel Trifunctional Salicylaldehyde Schiff Base Derivative with GPX, SOD and CAT Activities

作者：Li Huan Min; Gao Nan; Liu Lei; Shen Si Le; Luo Gui Min^*

来源：Chemical Journal of Chinese Universities, 2009, 30(7): 1353-1356.

• Glutathione peroxidase
• Salicylaldehyde Schiff base
• Selenium
• Superoxide dismutase
• Catalase

Glutathione peroxidase ( GPX) is one of the most crucial antioxidant enzymes in a variety of organisms; it catalyzes the reduction of H(2)O(2) by reduced glutathione( GSH). We used, sodium salicylaldehyde-5-sulfonate as the parent of the mimic, then the catalytic group of GPX, -SeH, was introduced to obtain a salicylaldehyde Schiff base compound, which was chelated with Mn and oxidized in air to obtain the final product. Its structure was proved by NMR, MS, IR and its antioxidant ability was tested. The product was demonstrated to have GPX, SOD and CAT activities at the same time, good solubility in water and strong ability to resist oxidative damage. Thus, the trifunctional enzyme mimic possesses a good potential in medicinal application.

• 出版日期2009-7-10
• 单位吉林大学