Second myeloablative allogeneic stem cell transplantation (SCT) using cord blood for leukemia relapsed after initial allogeneic SCT

作者：Konuma Takaaki; Ooi Jun^*; Takahashi Satoshi; Tomonari Akira; Tsukada Nobuhiro; Kato Seiko; Sato Aki; Monma Fumihiko; Kasahara Senji; Uchimaru Kaoru; Iseki Tohru; Tojo Arinobu; Asano Shigetaka

来源：Leukemia Research, 2009, 33(6): 840-842.

DOI：10.1016/j.leukres.2008.10.003

• Cord blood transplantation
• Second transplantation
• Leukemia
• Relapse
• Graft-versus-leukemia effect

There are many reports of second allogeneic stern cell transplantation (allo-SCT) using cord blood (CB) for graft failure after initial allo-SCT. However, the efficacy of second allo-SCT using CB for patients with leukemia relapsed after initial allo-SCT is unknown. We report the results of second allo-SCT using CB in seven adult patients with leukemia relapsed after initial allo-SCT. All patients received a myeloablative conditioning regimen including oral busulfan 16 mg/kg, intravenously fludarabine 100 mg/m(2) and cyclophosphamide 120 mg/kg. All but one patient had myeloid reconstitution and four patients remain alive at between 4 and 40 months after second SCT. We conclude that second myeloablative allo-SCT using CB may be feasible in selected patients with the relatively younger age, less organ damage and longer time interval between first and second allo-SCT.

• 出版日期2009-6
• 单位河北医科大学