Using biomaterials to modulate chemotactic signaling for central nervous system repair

作者：Hickey Kassondra; Stabenfeldt Sarah E^*

来源：Biomedical Materials (Bristol), 2018, 13(4): 044106.

DOI：10.1088/1748-605X/aaad82

• chemotaxis
• stroke
• traumatic brain injury
• spinal cord injury
• drug delivery
• central nervous system

Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.

• 出版日期2018-7